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Versa-Dome and Posi-Dome are compact, energy efficient and designed for practical use and ease of manufacture.  Heavy glove box and laminar hood devices are more expensive to buy, more difficult to install and operate and more challenging to maintain, but they do have advantages for some applications.

Versa-Dome & Posi-Dome vs Older, More Massive Isolation:
Selection Criteria Versa-Dome Posi-Dome Heavy Glove Box Laminar Air Hood
Isolation Tecnology -> Pressurized Barrier Isolation Pressurized Barrier Isolation Pressurized Barrier Isolation Laminar Air Wash
Materials of Construction-> Space age polymers: PETG, ABS, Delryn, Polyester, etc. Space age polymers: PETG, ABS, Delryn, Polyester, etc Steel & tempered glass Steel & tempered glass
Footprint & Weight-> 2.9 sq. feet;  13.3 lbs. 2.9 sq. feet;  12.6 lbs. 9 to 16 sq feet;  160 to 600+ lbs 5 to 14 sq feet;  40 to 190+ lbs
Operating complexity-> Easy protocols when closed. Must be attentive when loading, unloading & purging Easy protocols when closed. Must be attentive when loading, unloading & purging Challenging to set up and maintain, especially chemical dry train and vacuum pump operation & maintenance. Must be attentive when loading, unloading & purging; most depend on control systems and instruments requiring adjustment, calibration and parts replacement Very critical operating protocols at all times during operation, as direct contamination is a constant risk.  Sensor and controls calibration, test and recertification (by specialists) is required frequently to ensure protection is active and functional
Speial Atmosphere Use-> Yes - Standard Yes - Standard Yes - typically available No
Clean/Aseptic Use-> Yes - Standard Yes - Standard on most models Possible, though sterilization may be challenging Yes - Standard in clean room, laminar bench and biosafety cabinet equipment
Safe use with toxins or pathogens-> Yes - Standard May be possible, but it is not standard or fail-safe May be possible, but it depends on specific model features & usage protocols No, except for Biological Safety Cabinets, used with a strigent protocol
Infrastructure & Environment Issues-> Requires gas supply or wall outlet access; Bench-mount or portable Requires gas supply or wall outlet access;
Bench-mount or portable
Requires a large, dedicated space; vacuum pumps have high-current electrical requirement and are loud in operation; if dry-train equipped, instrument tech maintenance is required periodically along with plumbing and chemical maintenance. Requires a large, dedicated space; fans have continuous electrical requirements and can be noisy;  typically imposes significant load on buildingHVAC systems. Biological Safety Cabinets and most hoods require frequent recertification by experts with special skills and tools; ductwork, building wall or ceiling pentrations and environmental permits are generally required.
Energy Use-> 0 to 10 watts 0 to 10 watts 500 to 2000 watts during purge.
40 to 700 watts in operation
180 to 600 watts continuous
Best For-> Special Atmosphere or Clean/Aseptic processing: Does exactly what is needed Special Atmosphere or Clean/Aseptic processing: Does exactly what is needed Long duration processes that require Extreme conditions of temperature or gas purity better than 200 parts per billion Clean or sterile work by very experienced technicians when excessive heat or smoke is produced during the process
Primary Risks-> Exposure when open - human error
Inadequate purge - human error
Exposure when open - human error
Inadequate purge - human error
Distraction from primary process goals can spoil the main process; catastrophic failure (implosion) during purge; equipment, instrument or control systems failure: vacuum pump, chemical dry train, variable speed fans, and inside lighting. Process failure during power interruption. Contact contamination due to human/protocol failure; distraction from primary process goals can spoil the main process; equipment, instrument or control systems failure: variable speed fans, filter breech, airflow turbulence, and inside lighting; Isolation failure during power interruption.
Advantages-> Flexible, efficient, "green", labor saving, ultra-reliable & simple, easy to use Flexible, efficient, "green", labor saving, ultra-reliable & simple, easy to use Large; may have extended temperature capabilities; theoretical high-purity capabilities Open front allows use by users with different size hands without glove changes; can be used for processes that generate excess smoke and heat
Costs: Initial->

Operating->
From $1970

$12/mo + Gas cost
From $1750

$12/mo + Gas cost
$9000 to $65000+

$60 to $140/mo + Gas cost
$6800 to $35000+

$70 to $330/mo

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